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Epigenetics

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John Wiley & Sons, Apr 30, 2008 - Science - 238 pages
Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.
  

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Contents

Introduction
1
Gene silencing by methylCpG binding proteins
6
DNAmethylation nucleosornes and the inheritance okhromatin structure and function
22
General discussion I
46
Heritable chromatin states induced by the Polycomb and trithorax group genes
51
The dynamics of globin gene expression and position effects
67
Multiple epigenetic events regulate matingtype switching of fission yeast
87
General discussion I1
104
The host defence function of genomic methylation patterns
187
Mammalian X chromosome inactivation
200
Methylation dynamics epigenetic fidelity and X chromosome structure
214
General discussion IV
228
Imprinting and gene silencing in mice and DrosophiZa
233
Making sense of imprinting the mouse and human IGF2R loci
251
Imprinted genes in the PraderWilli deletion
264
Final general discussion
280

Nuclear organization and silencing trafficking of Sir proteins
114
Epigenetic mechanisms in the regulation of the maize Suppressormutator transposon
133
Transgenepromoted epigenetic switches of chalcone synthase activity in petunia plants
144
General discussion I11
163
Gene silencing in plants relevance for genome evolution and the acquisition of genomic methylation patterns
168

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About the author (2008)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.

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