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21st chromosome 50 per cent abnormal adoption affected child affected children albino allergy anencephaly anomalies antibodies antigens average baby birth blood group cancer carrier cells Chapter cleft lip cleft palate clinical clubfoot concordance consanguineous counselor couple cousin marriages defects develop diabetes Dight Institute dislocation dominant gene Down's syndrome dysplasia environment environmental factors epileptic expected expression father females Follow-up fraternal twins frequency genetic counseling geneticist genotype girl harelip hereditary heredity heterozygous homozygous human genetics husband identical twins ILLUSTRATIVE EXAMPLES incidence inheritance males malformations marry mendelian mental retardation mongolism mongoloid mother mutation nervous system normal offspring pair of genes parents paternity patients pedigree physician population possible pregnancy present probably problem produced pyloric stenosis rare recessive gene relatives reproduction Request result Rh negative Rh positive Rhesus factors risk figures schizophrenia seizures siblings sibs spina bifida Table tion trait translocated trisomy tuberculosis usually