Casarett & Doull's Toxicology: The Basic Science of Poisons: The Basic Science of Poisons, Seventh Edition (Google eBook)
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Unit 2 Disposition of Toxicants
Unit 3 NonOrganDirected Toxicity
Unit 4 Target Organ Toxicity
3 other sections not shown
absorption acetaminophen activity adducts aflatoxin agents aldehyde oxidase allele alterations amines animals apoptosis aromatic assays bile binding biotransformation blood cancer carboxylesterases carcinogenesis carcinogens catalyzed cause cells cellular chemical chromosome compartment compounds concentration conjugation CYP enzymes cytochrome P450 cytosolic developmental toxicity DNA damage DNA repair dose dose–response Drug Metab effects electrophilic environmental enzymes epoxide example excretion exposure expression factors formation function gene genetic genotoxic glucuronide glutathione glutathione transferase hepatic human increased induced inhibition inhibitors interactions intestine involved kidney kinase levels lipid liver lung mammalian mechanisms membrane metabolism metabolites methylation mice microsomal mitochondrial molecular molecules mouse mutagenic Mutat Res organ oxidative oxygen pathway Pharmacol phenobarbital plasma polymorphisms potential produce proteins rats reactions reactive receptor reductase repair response risk assessment rodent role shown in Fig species studies substrates synthesis target teratogenic Teratology tion tissue toxicity Toxicol toxicology transcription transport tumor vitro vivo whereas xenobiotics