Analgesic and NSAID-induced kidney disease
Analgesic nephropathy, first recognized in 1950, was for two decades the most common cause of both acute and chronic renal failure in Australia and parts of Europe. This comprehensive text traces the story of the disease from its early description to its ultimately successful prevention. The etiology, pathology, diagnosis, and treatment are described by those who have played leading roles in elucidating the nature of the disease, and in persuading society to take effective measures to prevent its occurrence. The second section describes those renal disorders resulting from the use of newer non-steroidal anti-inflammatory drugs and paracetamol - disorders which are rising in frequency and may prove more difficult to prevent. Finally, the book considers the urothelial cancers caused by phenacetin-containing headache powders, a late outcome of analgesic abuse. With contributions from a distinguished international group of authors, this is a unique book on a challenging problem. Throughout the text, theory and practice are integrated, and attention is drawn to the valuable lessons gained from the study of the analgesic nephropathies.
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The biochemistry and pharmacology of antipyreticanalgesics
Experimental evidence for nephrotoxicity of analgesics
The implication of analgesics in human kidney disease
16 other sections not shown
acetaminophen acid acute renal failure American Journal analgesic abuse analgesic consumption analgesic intake analgesic mixtures analgesic nephropathy analgesic patients animals antipyrine aspirin associated Australia Bach Bengtsson biopsy Burry caffeine capillary sclerosis carcinogenesis carcinogenicity carcinoma cause cell cent chronic renal Ciabattoni clinical compound analgesics cyclooxygenase dialysis dose Dubach Duggin enzyme epidemiological excretion experimental gastric glomerular Gloor hepatic hypertension increased indomethacin induced inhibition interstitial nephritis Johansson Journal of Medicine kidney kidney disease Kidney International Kleinknecht lesions liver McCredie Medical Journal medullary mesangial metabolism metabolites mg/kg/day Mihatsch necrotic papillae Nephrology nephrotic syndrome nephrotoxicity non-steroidal anti-inflammatory drugs NSAIDs papillae paracetamol Pathology patients with analgesic PGE2 Pharmacology phenacetin phenacetin-containing analgesics prostaglandin proteinuria pyelonephritis rats renal disease renal function renal insufficiency renal papillary necrosis renal pelvic cancer renal pelvis renal PG synthesis reported risk salicylate sodium studies sulindac Table therapy tissue toxicity transplantation tubular necrosis tubules tumours ureter urinary tract urine