The early effects of radiation on DNA
Springer-Verlag, 1991 - Medical - 430 pages
The latest theories and results on the early effects of radiation on DNA are presented and summarised in this text. Contributions are made by leading radiation physicists, chemists and biologists. All three subject areas have shown great advances in recent years, e.g. the computer codes and Monte Carlo calculations used by physicists, the deeper understanding of free radical intermediates by chemists, and the techniques of molecular biology. The reader will gain an insight into the different scientific languages and approaches used by physicists, chemists and biologists in the understanding of the effects of radiation on living matter.
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THE INTERDISCIPLINARY APPROACH TO RADIATION ACTION
Biophysical Models of Radiation Action
Links between Radiation Track Structure Radiochemical Species
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54 The Early adducts anion aqueous solution assay base damage base radicals Berlin Heidelberg 1991 calculated cell cycle cell killing cellular Chem chemical repair chromatin chromosome aberrations concentration curves cytosine decay DNA damage DNA double-strand breaks DNA dsb DNA Edited DNA molecule DNA radicals double strand breaks Early Effects Effects of Radiation electron trapping energy deposition Fielden filter elution formation Goodhead guanine high-LET induced initial Int J Radiat interaction ionising ionizing radiation irradiation kinetics lethal low LET mammalian cells measured mechanisms misonidazole misrepaired molecular neutrons nucleosome O'Neill OH radicals oxidation oxygen Phys produced proton purine Radiat Biol Radiat Res radiation action Radiation Biology Radiation on DNA radiation-induced radical cations radiosensitization rate constants RBE-values reaction redox scavengeable Schulte-Frohlinde sensitive simulation single-strand breaks Steenken studies sugar survival thiols thymine track structure V79 cells X-rays yield