Glass microelectrode studies on intramural papillary muscle cells: I. Description of preparation and studies on normal dog papillary muscle. II. Effects of circumflex coronary artery ligation
Northwestern University, Dept. of Pharmacology, 1974 - Medical - 163 pages
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60 minutes action potential amplitude action potential duration arrhythmia canine cardial cell layers cells in standard Circ circumflex coronary artery conduction velocity coronary ligation coronary occlusion curve cycle length dependency deep cells deep myocardial zone differences DMZ cells dogs dysrhythmia electrical activity electrodes electrograms electrophysiologic changes electrophysiologic characteristics electrophysiologic properties endo endocardial and epicardial endocardial surface endocardium epicardium extrasystoles fibrillation Figure heart impulse formation interelectrode conduction intramural cells ischemia ischemic isolated Jennings K+ concentration left ventricular M/sec maximum dV/dt membrane potential microelectrode msec myocardial infarction myocardial zone cells myocardium normal oscillations panel papillary muscle slice perfusion phase PM slice posterior papillary muscle poten PPM:ligated preparations PPM:ligated specimens PPM:sham prolonged Purkinje fibers repetitive firing repolarization responsiveness resting potential sham control shortening Solberg standard preparations standard surface preparations subendocardial and deep subendocardial cell subendocardial zone Tektronix tion tissue bath Transmembrane potentials Tyrodes upstroke velocity V/sec variability ventricle vitro