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absorption aizawai amino acid AMPC animals antibacterial activity antibiotic antibody assay B.t. kurstaki Bacillus thuringiensis bacteria binding carboxyl carnitine cDNA cefteram cell line cephalosporins cephem CFTM CFTM-PI Chem Chemotherapy Cloning compounds conjugate culture decreased detected dogs dose Drug effect enantiomers enzyme Ester-Type Oral Cephem excretion Flomoxef g/ml gene genomic Gram-negative Gram-positive Hiroshi human hydrogen bond increased induced infection inhibited inhibitors intestinal intramolecular hydrogen bond isolated Japanese Kenji levels liver mecA metabolic metabolites methicillin resistance method mg potency)/kg/day mg/kg group mice molecular mouse mRNA MRSA mutant observed oral administration oral cephem antibiotic patients PBP2 penicillin-binding protein peptide PGD2 PGE2 pharmacokinetics pinacidil pivalic acid pivaloylcarnitine pivaloyloxymethyl PLA2 plasma plasma concentration POM esters potent prostaglandin protein radioactivity rats renal sequence serovar serum Shionogi Shionogi Research Laboratories showed SISO spores Staphylococcus aureus strains Synthesis Thromboxane A2 tissue Tokyo toxicity study toxin Univ urine vitro Yoshida