Handbook of Brain Microcircuits (Google eBook)

Front Cover
Gordon Shepherd, MD, DPhil, Sten Grillner, MD
Oxford University Press, Aug 24, 2010 - Medical - 536 pages
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The information presented in the Handbook of Brain Microcircuits was previously dispersed across the literature. In fact, some microcircuits were previously brought together for selected regions in The Synaptic Organization of the Brain edited by Gordon Shepherd (2003) and Microcircuits edited by Sten Grillner and Ann Graybiel (2006). This handbook greatly extends that coverage to over 40 regions of the vertebrate and invertebrate nervous system becoming the go-to source for key circuits within the neurosciences. In order to focus on principles, each chapter is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit. The concept of microcircuits is emerging as one of the major organizing principles of the nervous system. Building on the foundation extending from Cajal, through the Editors' combined works above, to the present, the aim of this volume is several fold. First, the authors distil the current knowledge of synaptic and functional organization of each brain region so that the most basic aspects can be summarized in synthesizing microcircuit diagrams. Second, each diagram represents specific types of operations, and in so doing function as canonical circuits, that is, microcircuits that can be identified as carrying out generic operations that are essential to what a region contributes to the neural basis of behavior. Finally, by gathering these microcircuits within one volume, it becomes possible to begin identifying the canonical operations across different regions, that within each region are fine-tuned to the particular form of the information in that region and the output targets for the operations.
  

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About the author (2010)

Professor Shepherd was educated at Iowa State College and Harvard Medical School during the 1950s, and received further training at Oxford University, the National Institutes of Health, and Karolinska Institutet. He has been at the Yale University School of Medicine since 1967, and has held visiting positions at the University of Pennsylvania, College de France, Ecole Normale Superieure, Oxford University, and Institut Pasteur. In his research he and his collaborators introduced computational modeling into studies of brain neurons, revealed a new type of neuronal interaction between dendrites, and showed how smells are represented in the brain by distinct patterns of activity. His work has led to new concepts of brain organization, including the term microcircuits to describe canonical types of neuronal interactions. He has been editor in chief of the Journal of Neurophysiology and the Journal of Neuroscience. His books include The Synaptic Organization of the Brain, Neurobiology, and Creating Modern Neuroscience: The Revolutionary 1950s. His Foundations of the Neuron Doctrine was the first to focus on the dramatic events around the classical work on the neuron in the 19th and early 20th century. The present work takes up the even more dramatic events around the work at mid-20th century that established the modern neuroscience of today. Professor Grillner was educated at the University of Goteborg in Sweden. He is past Chairman if the Nobel Assemply at the Karolinska Institutet. Currently he is Director of the Nobel Institute for Neurophysiology at the Karolinska Institutet in Stockholm.

Professor Shepherd was educated at Iowa State College and Harvard Medical School during the 1950s, and received further training at Oxford University, the National Institutes of Health, and Karolinska Institutet. He has been at the Yale University School of Medicine since 1967, and has held visiting positions at the University of Pennsylvania, College de France, Ecole Normale Superieure, Oxford University, and Institut Pasteur. In his research he and his collaborators introduced computational modeling into studies of brain neurons, revealed a new type of neuronal interaction between dendrites, and showed how smells are represented in the brain by distinct patterns of activity. His work has led to new concepts of brain organization, including the term microcircuits to describe canonical types of neuronal interactions. He has been editor in chief of the Journal of Neurophysiology and the Journal of Neuroscience. His books include The Synaptic Organization of the Brain, Neurobiology, and Creating Modern Neuroscience: The Revolutionary 1950s. His Foundations of the Neuron Doctrine was the first to focus on the dramatic events around the classical work on the neuron in the 19th and early 20th century. The present work takes up the even more dramatic events around the work at mid-20th century that established the modern neuroscience of today. Professor Grillner was educated at the University of Goteborg in Sweden. He is past Chairman if the Nobel Assemply at the Karolinska Institutet. Currently he is Director of the Nobel Institute for Neurophysiology at the Karolinska Institutet in Stockholm.

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