Bile Acid Biology and Its Therapeutic Implications: Proceedings of the Falk Symposium 141 (XVIII Internationale Bile Acid Meeting) Held in Stockholm, Sweden, June 18 - 19, 2004 (Google eBook)

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G. Paumgartner
Springer Science & Business Media, Mar 2, 2005 - Medical - 270 pages
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This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 1819, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world.

Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics.

The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

  

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Contents

Multifunctional roles of bile acid biosynthetic enzymes and the isolation of a new vitamin D 25 hydroxylase
19
Studies on biosynthetic pathways to bile acids in human liver cells
27
Role of CYP3A4 as a cholesterol and bile acid metabolizing enzyme
37
New insights into bile acid amidation
41
Mechanisms of bile acid inhibition of bile acid synthesis
51
The farnesoid X receptor controls gene expression in a ligand and promoterselective fashion
59
Regulation of bile acid biosynthesis by cell signalling pathways
64
Feedback regulation of human bile acid synthesis
73
Haplotype analysis of hepatobiliary ABC transporter genes in cholecystolithiasis
147
Molecular elucidation of intestinal cholesterol absorption
153
BIOLOGICAL AND PHARMACOLOGICAL EFFECTS OF BILE ACIDS
169
Actions of the bile acid receptor FXR
171
Activation of MRP2 transport by ursodeoxycholic acid and its amidates
175
Role of mitogenactivated protein kinases in tauroursodeoxycholic acidinduced bile secretion in cholestatic rat liver
181
Bile acids and CD95 activation
184
Tauroursodeoxycholic acid a bile acid with in vivo antiapoptotic and neuroprotective properties
192

On the role of oxysterols in regulation of cholesterol homeostasis by nuclear receptors
80
TRANSPORT OF BILE ACIDS AND LIPIDS
89
Bile acid transport in Spgp Bsep knockout mice
91
Bile salt and glutathione coefflux mediated by multidrug resistance protein MRP4 ABCC4 a basolateral transporter of the hepatocyte
101
Role of farnesoid X receptor in regulating bile salt transport and synthesis
107
Genderspecific expression of liver organic anion transporters
118
Molecular mechanisms of intestinal bile acid transport
122
Adaptive regulation of bile salt transporters in cholestasis the role of MRPs
130
Adaptive hepatobiliary transporter regulation by ursodeoxycholic acid
132
Molecular mechanism of biliary lipid secretion
138
BILE ACIDS AS THERAPEUTIC AGENTS
213
Clinical presentation and treatment of familial unconjugated hypercholanaemia
215
Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation transport and detoxification...
219
Dose effect of ursodeoxycholic acid used in the treatment of primary biliary cirrhosis and primary sclerosing cholangitis
225
Highdose ursodeoxycholic acid in the management of primary sclerosing cholangitis
230
Chemopreventive effect of ursodeoxycholic acid in primary sclerosing cholangitis?
242
Ursodeoxycholic acid and colorectal carcinogenesis
250
Intrahepatic cholestasis of pregnancy results from the Swedish observation and intervention trials
256
Index
263
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Page 1 - For the services rendered through his research into the constitution of the sterols and their connection with the vitamins.

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