Airway Mucus: Basic Mechanisms And Clinical Perspectives (Google eBook)

Front Cover
D.F. Rogers, Michael I. Lethem
Springer Science & Business Media, Sep 23, 1997 - Medical - 388 pages
0 Reviews
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
  

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Airway Surface Liquid Concepts and Measurements
1
Structure and Biochemistry of Human Respiratory Mucins
19
Airway Mucin Genes and Gene Products
41
The Microanatomy of Airway Mucus Secretion
67
Mechanisms Controlling Airway Ciliary Activity
91
Rheological Properties and Hydration of Airway Mucus
117
Goblet Cells Physiology and Pharmacology
149
Airway Submucosal Glands Physiology and Pharmacology
179
Experimental Induction of Goblet Cell Hyperplasia In Vivo
227
Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmonary Disease
275
Mucus and Airway Epithelium Alterations in Cystic Fibrosis
301
DrugMucus Interactions
327
Therapeutic Approaches to the Lung Problems in Cystic Fibrosis
341
Therapeutic Approaches to Airway Mucous Hypersecretion
365
Index
385
Copyright

MucusBacteria Interactions
211

Common terms and phrases

Popular passages

Page 358 - Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis.
Page 362 - Engelhardt, JF, Yankaskas, JR, Ernst, SA, Yang, Y., Marino, CR, Boucher, RC, Cohn, JA, and Wilson, JM ( 1992).

Bibliographic information