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abnormal affected child affected children affected males alleles amino acid anemia antibody antigens autosomal dominant autosomal recessive biochemical birth blood group blood group system carrier cent centromere cholinesterase chromo clinical codon color blind common congenital malformations defect dermal patterns dermatoglyphics diabetes diagnosis disease disorders donor Down's syndrome enzyme example females fetal fetus Figure frequency G6PD gametes genotype globin graft hemoglobin hemolytic heterozygotes heterozygous homologous homozygotes homozygous human incidence individual inheritance karyotype known linkage loci locus maternal mating meiosis meiotic division metabolism molecule mother mutation MZ twins nondisjunction normal occur offspring onset age pair parents patients pedigree phenotype placenta population possible prenatal probability produce progeny protein rare recessive genes red cells relatives secretor sequence serum sex chromatin sex chromosomes shown sibs sibships sickle cell single specific synthesis tion tissue trait translocation trisomy types usually variants X chromosome zygotes