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administration of nicotine adrenal glands air pollution airway resistance Ancel Keys angina pectoris aortic sclerosis atherosclerosis autopsy ballistic Bantu blood lipid blood pressure California carbon monoxide carboxyhemoglobin carcinogenic cardiovascular disease catecholamines cent cholesterol cholesterol levels chronic bronchitis cigaret smoke cigarets a day circulatory clinical coronary artery disease coronary blood flow coronary disease coronary flow coronary heart disease correlation diet dietary differences dogs dose effects of smoking electrocardiographic Epidemiology epidemiology of heart epinephrine examination factors fetal genetic groups Health heart rate heavy smokers higher Hospital hypertension influence infusion inhalation injection intravenous investigator large number left ventricular lesions lipid Medical metabolism myocardial infarction myocardial oxygen National Heart Institute nicotine nicotine produced norepinephrine normal subjects observed patients physical activity physiologic population questionnaire respiratory result saturated serum cholesterol single cigaret smokers and nonsmokers smoking a single smoking habits smoking history stimulation study of coronary suggested surveys tobacco smoke venous tone York