Isotope Effects In Chemistry and Biology (Google eBook)
Amnon Kohen, Hans-Heinrich Limbach
CRC Press, Nov 1, 2005 - Science - 1096 pages
The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biological, and environmental sciences.
The authors first explain how kinetic, equilibrium, and anharmonic isotope effects are used to measure the ratio of reaction rates, the ratio between isotopes in thermodynamic equilibrium, and the geometric changes between molecules. The volume describes basic theories, including gas phase, simple condensed phase, small molecule studies, and applications of the Bigeleisen-Mayer theory before covering how isotopes affect molecular geometries, chemical bond breaking, formation and chemical dynamics, and hydrogen transfer. It explores novel, mass-independent isotope effects and problems encountered in hydrogen transfer, tunneling, and exchange. Authors also discuss isotope effects in organic and organometallic reactions and complex enzyme reactions and a unique chapter explores water isotope effects under pressure.
Written by internationally recognized researchers from 13 countries, some chapters summarize the perspective of a well-established subject while others review recent findings and on-going research that occasionally present controversial viewpoints using clear scientific arguments and discussion presented by all relevant authors. Isotope Effects in Chemistry and Biology brings together a wide scope of different perspectives and practical developments and applications into a comprehensive reference of isotope effects that reflect the most current state of the art.
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Chapter 3 Comments on Selected Topics in Isotope Theoretical Chemistry
Chapter 4 Condensed Matter Isotope Effects
Chapter 5 Anharmonicities Isotopes and IR and NMR Properties of HydrogenBonded Complexes
Chapter 6 Isotope Effects on HydrogenBond Symmetrization in Ice and Strong Acids at High Pressure
Chapter 7 Hydrogen Bond Isotope Effects Studied by NMR
Single and DoubleWell Potential
Chapter 24 Oxygen18 Isotope Effects as a Probe of Enzymatic Activation of Molecular Oxygen
Chapter 25 Solution and Computational Studies of Kinetic Isotope Effects in Flavoprotein and Quinoprotein Catalyzed Substrate Oxidations as Probe...
Chapter 27 Mechanisms of CHBond Cleavage Catalyzed by Enzymes
Chapter 28 Kinetic Isotope Effects as Probes for Hydrogen Tunneling in Enzyme Catalysis
Chapter 29 Hydrogen Bonds TransitionState Stabilization and Enzyme Catalysis
Chapter 30 Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions
Chapter 31 Catalysis by Alcohol Dehydrogenases
Chapter 9 NMR Studies of Isotope Effects of Compounds with Intramolecular Hydrogen Bonds
Chapter 10 Vibrational Isotope Effects in Hydrogen Bonds
Chapter 11 Isotope Selective Infrared Spectroscopy and Intramolecular Dynamics
Chapter 12 NonmassDependent Isotope Effects
Chapter 13 Isotope Effects in the Atmosphere
Chapter 14 Isotope Effects for Exotic Nuclei
Chapter 15 Muonium 8212 An UltraLight Isotope of Hydrogen
Chapter 16 The Kinetic Isotope Effect in the PhotoDissociation Reaction of ExcitedState Acids in Aqueous Solutions
Chapter 17 The Role of an InternalReturn Mechanism on Measured Isotope Effects
Chapter 18 Vibrationally Enhanced Tunneling and Kinetic Isotope Effects in Enzymatic Reactions
Chapter 19 Kinetic Isotope Effects for ProtonCoupled Electron Transfer Reactions
Chapter 20 Kinetic Isotope Effects in Multiple Proton Transfer
Chapter 22 Variational TransitionState Theory and Multidimensional Tunneling for Simple and Complex Reactions in the Gas Phase Solids Liquids a...
Chapter 23 Computer Simulations of Isotope Effects in Enzyme Catalysis
Chapter 32 Effects of High Hydrostatic Pressure on Isotope Effects
Proton Transfer through Intervening Water Molecules
Chapter 34 Isotope Effects from Partitioning of Intermediates in EnzymeCatalyzed Hydroxylation Reactions
Chapter 35 Chlorine Kinetic Isotope Effects on Biological Systems
Chapter 36 Nucleophile Isotope Effects
Chapter 37 Enzyme Mechanisms from Isotope Effects
Applications of Isotopes and Isotope Effects
Chapter 39 Secondary Isotope Effects
Chapter 40 Isotope Effects in the Characterization of Low Barrier Hydrogen Bonds
Chapter 41 Theory and Practice of Solvent Isotope Effects
acid activation adiabatic anharmonicity approximation barrier benzene Bigeleisen Biochemistry calculations carbon catalytic Chem chemical shifts chemistry classical coefficient complex contribution correlation corresponding coupling constants deuterated deuterium deuterium isotope effects dissociation distance dynamics electron transfer energy surface enrichment enzyme catalysis Equation exchange excitation experimental Figure force constants free energy frequency geometries H-bond hydrogen bond hydrogen tunneling interaction intramolecular ionization isotope separation isotopic fractionation isotopologues isotopomers KIEs kinetic isotope effects Klinman laser liquid mass measured modes molecular molecules motion nuclear observed obtained oxidation oxygen parameters partition function phase Phys potential energy potential energy surface protein proton transfer proton vibrational quantum mechanical rate constant reactant reaction coordinate resonance solution solvent spectra spectroscopy structure studies substrate symmetric temperature dependence theoretical theory transfer reactions transition transition state theory transition-state Truhlar values vibrationally VPIE zero-point energy