Isotope Effects In Chemistry and Biology (Google eBook)

Front Cover
Amnon Kohen, Hans-Heinrich Limbach
CRC Press, Oct 31, 2014 - Science - 1096 pages
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The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biological, and environmental sciences.

The authors first explain how kinetic, equilibrium, and anharmonic isotope effects are used to measure the ratio of reaction rates, the ratio between isotopes in thermodynamic equilibrium, and the geometric changes between molecules. The volume describes basic theories, including gas phase, simple condensed phase, small molecule studies, and applications of the Bigeleisen-Mayer theory before covering how isotopes affect molecular geometries, chemical bond breaking, formation and chemical dynamics, and hydrogen transfer. It explores novel, mass-independent isotope effects and problems encountered in hydrogen transfer, tunneling, and exchange. Authors also discuss isotope effects in organic and organometallic reactions and complex enzyme reactions and a unique chapter explores water isotope effects under pressure.

Written by internationally recognized researchers from 13 countries, some chapters summarize the perspective of a well-established subject while others review recent findings and on-going research that occasionally present controversial viewpoints using clear scientific arguments and discussion presented by all relevant authors. Isotope Effects in Chemistry and Biology brings together a wide scope of different perspectives and practical developments and applications into a comprehensive reference of isotope effects that reflect the most current state of the art.
  

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Contents

Chapter 1 Theoretical Basis of Isotope Effects from an Autobiographical Perspective
1
Chapter 2 Enrichment of Isotopes
41
Chapter 3 Comments on Selected Topics in Isotope Theoretical Chemistry
89
Chapter 4 Condensed Matter Isotope Effects
119
Chapter 5 Anharmonicities Isotopes and IR and NMR Properties of HydrogenBonded Complexes
153
Chapter 6 Isotope Effects on HydrogenBond Symmetrization in Ice and Strong Acids at High Pressure
175
Chapter 7 Hydrogen Bond Isotope Effects Studied by NMR
193
Single and DoubleWell Potential
231
Chapter 24 Oxygen18 Isotope Effects as a Probe of Enzymatic Activation of Molecular Oxygen
645
Chapter 25 Solution and Computational Studies of Kinetic Isotope Effects in Flavoprotein and Quinoprotein Catalyzed Substrate Oxidations as Probe...
671
Chapter 26 Proton Transfer and Proton Conductivity in Condensed Matter Environment
691
Chapter 27 Mechanisms of CHBond Cleavage Catalyzed by Enzymes
725
Chapter 28 Kinetic Isotope Effects as Probes for Hydrogen Tunneling in Enzyme Catalysis
743
Chapter 29 Hydrogen Bonds TransitionState Stabilization and Enzyme Catalysis
765
Chapter 30 Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions
793
Chapter 31 Catalysis by Alcohol Dehydrogenases
811

Chapter 9 NMR Studies of Isotope Effects of Compounds with Intramolecular Hydrogen Bonds
253
Chapter 10 Vibrational Isotope Effects in Hydrogen Bonds
281
Chapter 11 Isotope Selective Infrared Spectroscopy and Intramolecular Dynamics
305
Chapter 12 NonmassDependent Isotope Effects
361
Chapter 13 Isotope Effects in the Atmosphere
387
Chapter 14 Isotope Effects for Exotic Nuclei
417
Chapter 15 Muonium 8212 An UltraLight Isotope of Hydrogen
433
Chapter 16 The Kinetic Isotope Effect in the PhotoDissociation Reaction of ExcitedState Acids in Aqueous Solutions
451
Chapter 17 The Role of an InternalReturn Mechanism on Measured Isotope Effects
465
Chapter 18 Vibrationally Enhanced Tunneling and Kinetic Isotope Effects in Enzymatic Reactions
475
Chapter 19 Kinetic Isotope Effects for ProtonCoupled Electron Transfer Reactions
499
Chapter 20 Kinetic Isotope Effects in Multiple Proton Transfer
521
Chapter 21 Interpretation of Primary Kinetic Isotope Effects for Adiabatic and Nonadiabatic ProtonTransfer Reactions in a Polar Environment
549
Chapter 22 Variational TransitionState Theory and Multidimensional Tunneling for Simple and Complex Reactions in the Gas Phase Solids Liquids a...
579
Chapter 23 Computer Simulations of Isotope Effects in Enzyme Catalysis
621
Chapter 32 Effects of High Hydrostatic Pressure on Isotope Effects
837
Proton Transfer through Intervening Water Molecules
847
Chapter 34 Isotope Effects from Partitioning of Intermediates in EnzymeCatalyzed Hydroxylation Reactions
861
Chapter 35 Chlorine Kinetic Isotope Effects on Biological Systems
875
Chapter 36 Nucleophile Isotope Effects
893
Chapter 37 Enzyme Mechanisms from Isotope Effects
915
Applications of Isotopes and Isotope Effects
931
Chapter 39 Secondary Isotope Effects
955
Chapter 40 Isotope Effects in the Characterization of Low Barrier Hydrogen Bonds
975
Chapter 41 Theory and Practice of Solvent Isotope Effects
995
Chapter 42 Enzymatic Binding Isotope Effects and the Interaction of Glucose with Hexokinase
1019
Index
1055
Back cover
1075
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