DNA Vaccines: A New Era in VaccinologyMargaret A. Liu, Maurice R. Hilleman, Reinhard Kurth This conference provides an evaluation of current research on the powerful new technology of DNA vaccines. DNA vaccines hold great promise for prevention and immunotherapy of viral and parasitic infections and cancer, particularly those diseases for which development of traditional vaccines has proved difficult. Preclinical studies recently demonstrated the potential for polynucleotides encoding proteins from pathogens to be a novel and effective means of vaccination, generating cellular and antibody responses while avoiding the potential risks of approaches utilising live viruses. |
Contents
Overview of DNA Vaccines By MARGARET A LIU | 15 |
Potential DNA Vaccine Integration into Host Cell Genome By WARREN | 30 |
Protective Efficacy of Intramuscular Immunization with Naked DNA | 40 |
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Common terms and phrases
Acad adeno-associated virus adenovirus animals anti-DNA antibodies antibody responses antigen assay bacterial DNA BALB/c BALB/c mice Biol biological cancer cationic lipid CD8+ cell culture cell lines cell responses cellular immune challenge clinical CTL activity cytokine cytotoxic T lymphocytes Direct gene transfer disease DNA encoding DNA injection DNA vaccines dose efficacy ELISA epitopes gene delivery gene expression Gene Ther gene therapy genetic genome glycoprotein HBsAg hepatitis human idiotypic immune responses immunogen Immunol inactivated induced influenza injection of DNA inoculation insertion integration levels lysis M. A. LIU mice molecules monkeys mouse muscle cells naked DNA Natl nucleic acid nucleic acid vaccines P. L. FELGNER peptide plasmid DNA potential Proc production protective immunity protein rabies virus replication reporter gene safety scFv sequences sera serum specific studies target cells tion tissue titers transfected tumor ULMER uptake Virol viruses vitro vivo