The Origins of Genome Architecture

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Sinauer Associates, 2007 - Medical - 494 pages
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With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter. Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.

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Review: Origins of Genome Architecture

User Review  - Bastian Greshake - Goodreads

Good starting point if you're new to the topic to genomics Read full review

Review: Origins of Genome Architecture

User Review  - Elizabeth - Goodreads

As recommended by Eugene Koonin during a seminar hosted by the Department of Molecular Biology and Genetics entitled "The origin and nature of the major innovations of eukaryogenesis". Read full review


The Stem Eukaryote
Genome Size and Complexity
Population Size and the Mutational Hazard of Excess DNA

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About the author (2007)

MICHAEL LYNCH is a Distinguished Professor in the Department of Biology at Indiana University, Bloomington, USA.

BRUCE WALSH is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona, USA.

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