Introduction to Strategies for Organic Synthesis
Laurie S. Starkey
John Wiley & Sons, Feb 21, 2012 - Science - 340 pages
The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework
Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities.
Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis.
Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made.
Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
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1 Synthesis of Alcohols ROH
2 Synthesis of Alkyl RX and Aryl Halides ArX
3 Synthesis of Ethers ROR
Problems Target Molecules with Two Functional Groups
1 Electrophilic Aromatic Substitution
2 Synthesis of Aromatic TMs via Diazonium Salts
Problems Aromatic TMs
1 Synthesis of Cyclopropanes
3 Synthesis of FiveMembered Rings Radical
Problems Cyclic TMs
4 Synthesis of Thiols RSH and Thioethers RSR
5 Synthesis of Amines RNH2 and Anilines
Retrosynthesis of Alkanes
Synthesis of AldehydesKetones via Acyl
10 Synthesis of Carboxylic Acids RCO2H
11 Synthesis of Carboxylic Acid Derivatives
Problems Monofunctional Target Molecules 1FG TMs
Synthesis of Target Molecules with Two Functional
Synthesis of αβUnsaturated Esters Using
The Michael Reaction
1 Reactions That Form Racemates
4 Additions to Alkenes and Alkynes
Nucleophiles Electrophiles and Redox
Difunctional Target Molecules 2FG TMs