Tumor Models in Cancer Research (Google eBook)

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Springer Science & Business Media, Dec 1, 2010 - Medical - 708 pages
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The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
  

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Contents

Part II Transplantable Syngeneic Rodent Tumors
21
Part III Human Tumor Xenografts
96
Part IV CarcinogenInduced Tumors
242
Part V Disease and TargetSpecific Models
256
Part VI Genetically Engineered Mouse Models of Cancer
374
Part VII Metastasis Models
444
Part VIII Normal Tissue Response Models
496
Part IX Experimental Methods and Endpoints
569
Index
680
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