Tumor Models in Cancer ResearchBeverly A. Teicher The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease. |
Contents
| 21 | |
Part III Human Tumor Xenografts | 96 |
Part IV CarcinogenInduced Tumors | 242 |
Part V Disease and TargetSpecific Models | 256 |
Part VI Genetically Engineered Mouse Models of Cancer | 374 |
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adenocarcinoma agents anesthesia angiogenesis animal models antibody anticancer drug antigen apoptosis assays Biol blood bone marrow breast cancer cancer cells cancer research canine carcinoma cell lines chemotherapy Clin Cancer Res clinical trials clonogenic colonies cyclophosphamide cytotoxic disease dose drug development effects efficacy evaluation experimental expression fluorescent gemcitabine gene genetic growth factor human tumor xenografts imaging implanted induced inhibition inhibitor injection kinase lesions leukemia liver lung lymphoma malignant mammary mammary tumors melanoma mesothelioma metastasis metastatic molecular mouse models mucositis murine mutations nude mice nude mouse Oncogene Oncol oncology orthotopic pancreatic pancreatic cancer pathways patients PDAC potential preclinical primary tumor prostate cancer protein radiation receptor renal renal cell carcinoma Renca response screening solid tumors specific spontaneous stem cells studies survival target Teicher therapeutic therapy tissue toxicity TRAMP transgenic transgenic mice transplantable treatment tumor cells tumor growth tumor models vascular VEGF vitro vivo xenograft xenograft models