Rho GTPases (Google eBook)

Front Cover
Marc Symons
Springer Science & Business Media, May 31, 2004 - Science - 235 pages
0 Reviews
Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins.
This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility.
Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.
  

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Contents

Signalling Networks of Rho GTPases
1
Biological Activities of Unconventional Rho Proteins
3
Signalling Networks Controlled by Rho Proteins in Mammals
8
Concluding Remarks
10
Intracellular Targeting of Rho Family GTPases Implications of Localization on Function
17
Targeting MotifsLocation Location Location
19
CTerminal Targeting MotifsThe Importance of Being Hypervariable
25
TC10 and Cdc42A Tail of Two GTPases
26
Regulation of Cadherin Function
122
Signalling from Cadherin Receptors
130
Conclusions
132
Rho GTPases and Cell Motility
141
Rho GTPases and Cell Polarity
142
Actin Polymerization at the Leading Edge
145
Remodeling Focal Contacts
148
The Generation of Contractile Force
150

RhoGDIThe Catcher in the Cytosol
27
ConclusionsYou Are Where You Are
28
Regulation of the RhoGTPases by RhoGDI
32
GDIs As Multifunctional Regulators of Signalling through Rho GTPases
33
Structural Insights into GDI Function
35
Future Directions
41
Conclusion
43
Rho Family Guanine Nucleotide Exchange Factors
46
Structure of RhoGEFs
49
Regulation of RhoGEFs
50
Physiological Roles for RhoGEFs
56
RhoGEFs and Human Disease
61
Future Perspectives
63
The Superfamily of Rho GTPaseActivating Proteins
68
Molecular Basis of the GTPaseStimulating Activity
72
RhoGAPs Are Multifunctional Proteins
74
RhoGAPs in HostPathogen Interaction
81
Conclusion
85
Rnd Proteins Intriguing Members of the Rho Family
96
Chromosomal Localization
98
Do Rnd Proteins Need GEFs for Activation
99
Localization of Rnd1 in Swiss 3T3 Fibroblasts and Microinjected MDCK Cells
101
Proteins Interacting with Rnds
102
Induced Expression of Rnd3 Participates in the Transformation of Epithelial Cells by Raf
103
Rnds in Development
104
Rho GTPases in the Organization of the Actin Cytoskeleton
107
Membrane Ruffles Filopodia and Stress Fibres
108
ActinMyosin II Contractility and Stress Fibre Formation
109
Controlling Actin Treadmilling
110
Arp23Mediated Actin Nucleation and Branching
111
Tethering Assembled Actin to Membranes
112
CellCell Adhesion
115
Cadherin Receptors
117
Experimental Models to Investigate CellCell Adhesion Regulation
120
Summary
152
The RhoGTPase in Tumor Invasion
155
RHO Involvement in Tumor Progression
156
Mechanisms of Rho Involvement in Invasion
157
Conclusions
159
Rho Family GTPases and Cellular Transformation
163
Rho GTPases Function As MembraneAssociated GDP GTPRegulated Molecular Switches
164
Rho Family GTPases Are Critical Components of Diverse Signalling
169
Rho GTPases Promote Oncogenic Transformation
170
Rho GTPases Mediate Transformation through Multiple Effectors
175
Conclusions and Future Directions
177
Rho GTPases in Lipid Metabolism
185
RacMediated Arachidonic Acid Release
188
Rho A As an Effector of Arachidonic Acid Metabolism
190
Phospholipase D As an Effector of Rho Family GTPases
191
Final Considerations
192
The Role of Rho GTPases in Vesicle Trafficking
196
Macropinocytosis
199
Exocytosis
201
Trafficking in Polarized Epithelial Cells
202
Trafficking Controlled by Rho GTPases in the Regulation of Cell Motility and CellCell Junctions
203
The Dictyostelium Rho Family of Proteins and Effectors
208
An Overview of the Dictyostelium Rho Family of GTPases
209
Rho Family GTPase Regulators and Effectors
212
Other Proteins that Interact with Rho Family GTPases
215
Summary
216
Rho GTPases in Plants
219
Regulation of Rop
221
Rop Localization
222
RopRegulated Processes
223
Concluding Remarks
227
Index
231
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Page 205 - Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.
Page 228 - S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells, Cell 93:815-826.

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