Springer, May 31, 2004 - Science - 235 pages
Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility. Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.
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Signalling Networks of Rho GTPases
Biological Activities of Unconventional Rho Proteins
Signalling Networks Controlled by Rho Proteins in Mammals
Intracellular Targeting of Rho Family GTPases Implications of Localization on Function
Targeting MotifsLocation Location Location
CTerminal Targeting MotifsThe Importance of Being Hypervariable
TC10 and Cdc42A Tail of Two GTPases
Regulation of Cadherin Function
Signalling from Cadherin Receptors
Rho GTPases and Cell Motility
Rho GTPases and Cell Polarity
Actin Polymerization at the Leading Edge
Remodeling Focal Contacts
The Generation of Contractile Force
RhoGDIThe Catcher in the Cytosol
ConclusionsYou Are Where You Are
Regulation of the RhoGTPases by RhoGDI
GDIs As Multifunctional Regulators of Signalling through Rho GTPases
Structural Insights into GDI Function
Rho Family Guanine Nucleotide Exchange Factors
Structure of RhoGEFs
Regulation of RhoGEFs
Physiological Roles for RhoGEFs
RhoGEFs and Human Disease
The Superfamily of Rho GTPaseActivating Proteins
Molecular Basis of the GTPaseStimulating Activity
RhoGAPs Are Multifunctional Proteins
RhoGAPs in HostPathogen Interaction
Rnd Proteins Intriguing Members of the Rho Family
Do Rnd Proteins Need GEFs for Activation
Localization of Rnd1 in Swiss 3T3 Fibroblasts and Microinjected MDCK Cells
Proteins Interacting with Rnds
Induced Expression of Rnd3 Participates in the Transformation of Epithelial Cells by Raf
Rnds in Development
Rho GTPases in the Organization of the Actin Cytoskeleton
Membrane Ruffles Filopodia and Stress Fibres
ActinMyosin II Contractility and Stress Fibre Formation
Controlling Actin Treadmilling
Arp23Mediated Actin Nucleation and Branching
Tethering Assembled Actin to Membranes
Experimental Models to Investigate CellCell Adhesion Regulation
The RhoGTPase in Tumor Invasion
RHO Involvement in Tumor Progression
Mechanisms of Rho Involvement in Invasion
Rho Family GTPases and Cellular Transformation
Rho GTPases Function As MembraneAssociated GDP GTPRegulated Molecular Switches
Rho Family GTPases Are Critical Components of Diverse Signalling
Rho GTPases Promote Oncogenic Transformation
Rho GTPases Mediate Transformation through Multiple Effectors
Conclusions and Future Directions
Rho GTPases in Lipid Metabolism
RacMediated Arachidonic Acid Release
Rho A As an Effector of Arachidonic Acid Metabolism
Phospholipase D As an Effector of Rho Family GTPases
The Role of Rho GTPases in Vesicle Trafficking
Trafficking in Polarized Epithelial Cells
Trafficking Controlled by Rho GTPases in the Regulation of Cell Motility and CellCell Junctions
The Dictyostelium Rho Family of Proteins and Effectors
An Overview of the Dictyostelium Rho Family of GTPases
Rho Family GTPase Regulators and Effectors
Other Proteins that Interact with Rho Family GTPases
Rho GTPases in Plants
Regulation of Rop
Stimulation of phospholipase C-beta2 by the Rho gtpases cdc42hs ...
The results identify plcbeta2 as a novel effector of the Rho gtpases cdc42hs and Rac1, and as the first mammalian effector directly regulated by both ...
sciencedirect - Current Biology : Control of Vesicular Trafficking ...
Differential involvement of Rho gtpases in fcγr- and CR-mediated phagocytosis. .... Rho gtpases are also involved in clathrin-independent receptor ...
linkinghub.elsevier.com/ retrieve/ pii/ S0960982203003245
Eurekah - Rho gtpases in the Organization of the Actin Cytoskeleton
Rho gtpases in Plants. Aline H. Valster, Peter K. Hepler and Jonathan Chernoff ... The guanine nucleotide exchange factors for the Rho gtpases (rhogefs) are ...
www.eurekah.com/ chapter/ 1328
Stimulation of phospholipase C-[beta]2 by the Rho gtpases cdc42hs ...
2 as a novel effector of the Rho gtpases cdc42hs and Rac1, and as the first mammalian effector directly regulated by both heterotrimeric and ...
www.nature.com/ emboj/ journal/ v17/ n21/ full/ 7591316a.html
Activated Rho gtpases interact with cellular target proteins or ... ing, and Rho gtpases are likely to play a regulatory role ...
www.jbc.org/ cgi/ reprint/ 273/ 33/ 20685.pdf
Rho gtpases and Cancer
Like Ras proteins, most Rho gtpases function as molecular switches that .... of Rho gtpases by sequestering GDP-bound Rho proteins in the cytoplasm, ...
www.springerlink.com/ index/ p284877757412506.pdf
Biol. Cell (2006) 98, 577-588 - M. Coisy-Quivy and others - Rho ...
Identification of Rho gtpases implicated in terminal differentiation of muscle cells in ... Using the ascidian model to identify the role of Rho gtpases on ...
www.biolcell.org/ boc/ 098/ 0577/ boc0980577.htm
Review Ras and Rho gtpases: A Family Reunion
Rho gtpases argues for the physiological importance of ..... Rho gtpases, thus forming a molecular device for signal. ent agonists, LPS (lipopolysaccharide) ...
cmbi.bjmu.edu.cn/ news/ report/ 2004/ ras/ view/ 107.pdf
Role of Rho family gtpases in epithelial morphogenesis -- Van ...
As other members of the Ras superfamily, Rho gtpases cycle between a GDP-bound (inactive) state and a GTP-bound (active) state. In the active state, ...
www.genesdev.org/ cgi/ content/ abstract/ 16/ 9/ 1032
Regulation of xsnail2 expression by Rho gtpases
We analyzed the effects of Rho gtpases on xsnail2 expression during ... These results show that Rho gtpases can regulate the expression of xsnail2 during NC ...
doi.wiley.com/ 10.1002/ dvdy.21273