Th 17 Cells: Role in Inflammation and Autoimmune Disease: Role in Inflammation and Autoimmune Disease (Google eBook)

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Springer, Mar 12, 2009 - Medical - 256 pages
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With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.
  

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Contents

Preface
xi
Introduction
1
Discovery and IL17 family
12
Common and different properties
13
Invariant natural killer T cells
39
Repairing and protecting peripheral tissues
49
Retinoic acid in mucosal immuneregulation
61
IL25 another promoter of allergy
69
Role of IL23IL17 in infection and tumor control
133
Is IL17 required to control tuberculosis?
135
IL17 and mucosal host defense
149
IL23 orchestrates the switch from tumor immune surveillance to tumorpromoting inflammation
161
IL17 in clinical autoimmune disease
174
IL17 and Th17 cells in rheumatoid arthritis
175
Targeting Th17 cells in CNS immune pathology
185
IL17 cytokines in asthma
201

Experimental models of disease
81
Critical role of IL17 in experimental arthritis
83
Dual role of IL17 in allergic asthma
95
Contribution of IL17 to the pulmonary inflammatory response
105
The role of IL17 in experimental autoimmune myocarditis
115
Th17 cells in organ transplantation
127
IL1723 potential targets for Crohns disease
211
Novel tools and therapeutic avenues
225
IL17A and Th17 cells as therapeutic targets for autoimmune diseases
227
Index
241
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