Goodman and Gilman's The Pharmacological Basis of Therapeutics |
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Page 397
... antipsychotic drugs such as clo- zapine are characterized by their very weak actions or inactivity in such tests . Neuroleptic drugs inhibit a dopamine - sensitive adenylate cyclase system in homogenates of cau- date or limbic tissue ...
... antipsychotic drugs such as clo- zapine are characterized by their very weak actions or inactivity in such tests . Neuroleptic drugs inhibit a dopamine - sensitive adenylate cyclase system in homogenates of cau- date or limbic tissue ...
Page 398
... antipsychotic effects ; this may reflect their action outside the blood - brain barrier in the inferior hypothalamus or in the pituitary gland . There is little or no tolerance to the effect of antipsychotic drugs on prolactin , even ...
... antipsychotic effects ; this may reflect their action outside the blood - brain barrier in the inferior hypothalamus or in the pituitary gland . There is little or no tolerance to the effect of antipsychotic drugs on prolactin , even ...
Page 410
... antipsychotic drugs offer any advantage . A combination of an antipsychotic drug and an anti- depressant may be useful in some cases , especially in depressed psychotic patients or in cases of agi- tated depression . However , the ...
... antipsychotic drugs offer any advantage . A combination of an antipsychotic drug and an anti- depressant may be useful in some cases , especially in depressed psychotic patients or in cases of agi- tated depression . However , the ...
Contents
SECTION | 1 |
Mechanisms of DRUG ACTION AND THE RELATION | 35 |
PRINCIPLES OF THERAPEUTICS | 49 |
Copyright | |
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absorption acid action activity acute administration adrenergic agonists alcohol amines analgesia analgesic anesthesia anesthetic antagonists anti-ChE agents antidepressants antipsychotic arterial atropine autonomic B-adrenergic barbiturates benzodiazepines binding blockade blocking agents blood flow blood pressure brain cardiac cardiovascular catecholamines cause cells central Chapter chlorpromazine cholinergic chronic Clin clinical compounds concentration creased decrease depression diazepam disease dopamine dosage doses enflurane enzyme epinephrine excreted fects fibers function ganglia ganglionic gastrointestinal halothane hepatic hypotension increase inhalation inhibition inhibitors injection interactions intravenous levodopa lithium local anesthetics mechanisms membrane metabolism metabolites morphine muscarinic nephrine nerve nervous system neuroleptic neuromuscular neurons nicotinic norepinephrine occur opioids oral oxygen patients pentazocine peripheral Pharmacol pharmacological phenobarbital phenytoin plasma potential produce propranolol protein receptors reduced release renal reserpine respiratory response result seizures side effects sleep smooth muscle spinal stimulation sympathetic sympathomimetic Symposium symptoms therapeutic therapy tion tissues tive toxicity transmitter treatment tricyclic tricyclic antidepressants usually