Handbook of Schizophrenia Spectrum Disorders, Volume I: Conceptual Issues and Neurobiological AdvancesMichael S Ritsner A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients. |
Contents
| 1 | |
2 Diagnosis and Classification of the Schizophrenia Spectrum Disorders | 45 |
3 Toward a Multidimensional Continuum Model of Functional Psychoses for Research Purposes | 85 |
4 Irving Gottesman and the Schizophrenia Spectrum | 115 |
Reflections on the Bridge to Schizophrenia and Obstacles on the Road Ahead to Etiology and Pathogenesis | 127 |
6 Autistic Spectrum Disorders and Schizophrenia | 143 |
Genomic Psychological and Evolutionary Models of Autism in Relation to Schizophrenia | 163 |
8 Quantifying the Dynamics of Central Systemic Degeneration in Schizophrenia | 187 |
A Model for Biomarker Discovery in Schizophrenia | 327 |
16 What Does Proteomics Tell Us About Schizophrenia? | 345 |
Findings in Rodents Models and Clinical Populations | 367 |
18 Neural Substrates of Emotion Dysfunctions in Patients with Schizophrenia Spectrum Disorders | 405 |
A Review of the Evidence | 431 |
20 Mapping Prodromal Psychosis | 445 |
Afterword | 473 |
Contents to Volume II | 477 |
9 Schizophrenia Has a High Heritability but Where Are the Genes? | 219 |
10 Changes in Gene Expression in Subjects with Schizophrenia Associated with Disease Progression | 237 |
11 Amino Acids in Schizophrenia Glycine Serine and Arginine | 253 |
12 Developmental Consequences of Prenatal Exposure to Maternal Immune Activation | 263 |
13 Glutamatergic Neurotransmission Abnormalities and Schizophrenia | 287 |
14 Mathematical Models in Schizophrenia | 305 |
Common terms and phrases
abnormalities activation altered analysis approach Arch Gen Psychiatry assessment associated autism behavior Biol Psychiatry bipolar disorder brain changes clinical cognitive common compared complex controls cortex course criteria decreased deficits depression diagnostic disease dopamine dysfunction early effects emotion endophenotypes episode et al evidence expression factors findings functional gene genetic glutamate healthy hippocampus human identified imaging immune impairment increased individuals involved levels major matter measures memory mental negative neural neuroimaging neurons Neurosci observed offspring onset patients performance personality phenotypes positive potential prefrontal present processing protein Psychiatry psychopathology psychosis psychotic rats recent receptor reduced regions relatives reported response risk role Schizophr Res schizophrenia schizophrenia spectrum schizotypal severity showed significant similar social specific spectrum disorders stress structure studies subjects suggest symptoms syndrome temporal tion treatment University volume