Handbook of Schizophrenia Spectrum Disorders, Volume I: Conceptual Issues and Neurobiological Advances (Google eBook)

Front Cover
Michael S. Ritsner
Springer, Apr 6, 2011 - Psychology - 512 pages
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A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.
  

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Contents

1 The Schizophrenia Construct After 100 Years of Challenges
1
2 Diagnosis and Classification of the Schizophrenia Spectrum Disorders
45
3 Toward a Multidimensional Continuum Model of Functional Psychoses for Research Purposes
84
4 Irving Gottesman and the Schizophrenia Spectrum
115
Reflections on the Bridge to Schizophrenia and Obstacles on the Road Ahead to Etiology and Pathogenesis
127
6 Autistic Spectrum Disorders and Schizophrenia
143
Genomic Psychological and Evolutionary Models of Autism in Relation to Schizophrenia
163
8 Quantifying the Dynamics of Central Systemic Degeneration in Schizophrenia
187
A Model for Biomarker Discovery in Schizophrenia
327
16 What Does Proteomics Tell Us About Schizophrenia?
345
Findings in Rodents Models and Clinical Populations
367
18 Neural Substrates of Emotion Dysfunctions in Patients with Schizophrenia Spectrum Disorders
405
A Review of the Evidence
431
20 Mapping Prodromal Psychosis
445
Afterword
472
Contents to Volume II
477

9 Schizophrenia Has a High Heritability but Where Are the Genes?
219
10 Changes in Gene Expression in Subjects with Schizophrenia Associated with Disease Progression
237
11 Amino Acids in Schizophrenia Glycine Serine and Arginine
253
12 Developmental Consequences of Prenatal Exposure to Maternal Immune Activation
263
13 Glutamatergic Neurotransmission Abnormalities and Schizophrenia
287
14 Mathematical Models in Schizophrenia
305
Contents to Volume III
479
Contributors to Volume II
481
Contributors to Volume III
487
Index
491
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