Gene Therapy for Neoplastic DiseasesBrian Edward Huber, John S. Lazo This text discusses advances in applications of gene therapy for the treatment of neoplastic diseases. It contains discussions of gene therapy strategies, the construction of artificial genes and gene delivery systems. Ethical, regulatory and public policy issues in gene therapy are also considered. |
Contents
GENE THERAPY | 4 |
Cationic Liposomes for Direct Gene Transfer in Therapy of Cancer | 23 |
HighEfficiency Gene Transfer Mediated by AdenovirusPolylysineDNA | 36 |
Copyright | |
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Common terms and phrases
Acad activity adenovirus adenovirus vectors amphotropic antigen antisense antitumor assay autologous Biol bone marrow carcinoma cationic liposomes cDNA cell lines cell types cellular chimeric clinical trials clones complex conjugate cytokine cytosine deaminase cytotoxic deaminase disease drug effector effects efficiency encoding enzyme ex vivo factor FEM cells function Gaucher disease gene delivery gene expression Gene Ther gene transfer genetic genome glucocerebrosidase growth H-ras hematopoietic human gene therapy infection inhibition interleukin leukemia levels liposomes lymphocytes malignant marker MDR1 mediated melanoma melanoma cells mice molecular mouse murine mutant my-IFN myoblasts NABEL Natl normal ODNs oncogenes P-glycoprotein patients peripheral blood phenotype plasmid polylysine potential Proc protein protocol receptor recombinant replication Research resistance retroviral vectors ribozyme selection sequences specific stem cells strategy studies supernatants target cell therapeutic tissue toxicity trans transcription transduced transfection transplantation tumor cells tumorigenicity viral virus viruses vitro vivo gene