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Some Problems and Concepts
Iron and IronDerived Radicals
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a-tocopherol activity allopurinol alveolar macrophages antioxidant arachidonic acid Aust SD autoxidation Biol Chem biological blood brain Ca2+ calcium catalase catalyze cellular cerebral chelators Clin Invest concentrations cytochrome damage decrease deferoxamine disease dopamine electron endothelial cells endothelium enhanced enzyme evidence experimental fatty acids Fe2+ Fenton reaction ferric ferritin ferrous formation free radical Fridovich glomerular injury glomerulonephritis glutathione peroxidase GSSG Gutteridge JMC Halliwell human neutrophils hydrogen peroxide hydroperoxides hydroxyl radical IgA-immune immune complexes increased incubation induced inflammatory inhibit inhibitor initiation intracellular ions iron ischemic lactoferrin leukocytes lipid peroxidation lung injury macrophages mechanism mediated membrane metabolism microsomes mitochondria molecular monoamine oxidase myocardial infarction myocardial ischemia myocardium NADPH neurons neutrophils oxidant stress oxygen radicals paraquat phospholipids production prostaglandin proteins reactive reduced release reperfusion injury respiratory burst role scavengers species spinal cord stimulated studies superoxide dismutase synaptosomes tissue injury toxicity uptake vascular vitro vivo xanthine oxidase