Cardiovascular biology of purines
Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. In this book we focus on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions. Activation of different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated responses both pre- and post-junctionally, trigger and mediate ischaemic preconditioning, cause vasodilation and vasoconstriction and enhance endothelial proliferation and apoptosis as well as inhibit platelet and neutrophil function. This book covers the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasizes the interactions between these two signalling systems. Cardiovascular Biology of Purines covers topics ranging from molecular and cellular to systemic and clinical. It also aims to highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments. We hope that our book will prove to be timely and helpful.
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The Role of Peripheral Autonomic Neurons with P andor
Cardiac Physiology of Adenosine
Vascular Biology and Pharmacology of Adenosine Receptors
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action of adenosine adenine adenine nucleotides adenosine receptor adenosine release adenylyl cyclase aged hearts agonist angiogenesis antiadrenergic antiadrenergic action atrial Belardinelli Biochem Bumstock G Burnstock calcium cardiac myocytes cardiomyocytes cardioprotective effects Cardiovasc cardiovascular Circ Res cloned contractile response Cronstein Dobson JG effects of adenosine endothelial cells endothelium expression extracellular ATP Fenton RA function guinea-pig Harden TK hypoxia increase infarction inhibition inhibitor inotropic ischemia isolated isoproterenol KATP KATP openers Lerman mammalian mast cells mechanism mediated membrane metabolism modulation molecular mRNA myocardial myocardium neurons neutrophil nitric oxide nonfailing noradrenaline nucleotides P2X purinoceptors P2X receptors P2Xi P2Y receptors P2Yi pathway perfused pharmacological phosphorylation Physiol platelets potassium channels potential PPADS protein kinase protein-coupled purine purinergic receptors rabbit rat heart receptor agonists receptor antagonist reperfusion role selective signaling smooth muscle cells stimulation studies subunits suramin sympathetic tachycardia tissue transgenic vascular endothelial vascular smooth muscle vasodilation ventricular myocytes