Microcirculatory Effects of Hemoglobin Solutions

Front Cover
K. Messmer, Konrad Messmer, K. E. Burhop, J. Hutter
Karger Medical and Scientific Publishers, 2004 - Medical - 106 pages
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Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States. In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed. This volume summarizes the latest research on the effects of some of these new hemoglobin solutions on the microvasculature and tissue oxygenation. It is recommended reading for all those interested in finding alternatives for donor blood in transfusion medicine, including emergency specialists, anesthesiologists, surgeons, trauma surgeons and other clinicians who are frequently confronted with blood loss and the need for blood replacement.
  

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Contents

Shear Stress Effects on Endothelial Cells
1
Microvascular Transport Factors in the Design of Effective Blood Substitutes
8
Tissue Oxygen Effects of HBOC201 versus Red Blood Cells
16
DextranConjugated Hemoglobin Does Not Alter Microcirculatory Parameters after Moderate Hemodilution
27
Total Blood Exchange with Diaspirin Cross Linked Hemoglobin Is Compatible with Long Term Survival
39
The Development and Preclinical Testing of a SecondGeneration Recombinant Hemoglobin Solution rHb20 for Injection
48
Moderate Hemodilution with rHb20 for Injection
65
rHb20 for Injection for Resuscitation from Hemorrhagic Shock
75
Influence of HemoglobinBased Oxygen Carriers with Different Nitric Oxide Scavenging Properties on the Pancreatic Microcirculation after Hemorrh...
86
Background and Initial Preclinical Results with a Novel Second Generation Blood Substitute
95
Author Index
103
Subject Index
104
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Page 94 - Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion.
Page 101 - The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery, J.

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