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accepted adequate advance American Medical Association analgesic animals aspects benefit Cardiac catheterization Claude Bernard clinical research Committee concerned conducted controlled danger decision discussion disease doctor drug effects essential ethical and moral experimental subject full implications Guttentag 1953 hazard Hippocratic Oath human experi human experimentation human subjects individual injury interests Investigator Relationships judgment justify Ladimer Ladimir Lancet Lasagna LEGAL CONSIDERATIONS Mackintosh matter of consent medical ethic medical experiment medical knowledge medical practice medical research Medical Research Council ment mental mentation methods nature Nuremberg Military Tribunals Nuremberg Rule order of values pain Pellagra performed person physician physician-experimenter physician-friend placebo point number Pope Pius XII possible prac practice of medicine precedents present principle prisoners problem procedures protect Public Health reasons recognized risk involved scientific scientist study of subjective Subject and Investigator tation therapeutic therapy tion treatment trial United States Public volunteer welfare Wiggers World Medical Association