Cloning and characterization of clumsy (clu) a novel presynaptic glutamate receptor that regulates synaptic growth at the larval neuromuscular junction in Drosophila melanogaster
University of Wisconsin--Madison, 2008 - 88 pages
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Cloning and characterization of the TS paralytic
3rd instar adult APLIP average bouton number axonal transport axonal transport defects branch number cause overgrowth clumsy activity clumsy alleles clumsy mutants Confocal images decrease in bouton different from wild-type dominant negative Drosophila Drosophila melanogaster elav3AGal4 encodes expression of Clumsy expression of wild-type Figure flies function allele function mutations G protein gain of function Gal4 driver genes genetic GluR5 GluRIIA hippocampus hyperbranching interacting ion channel ionotropic glutamate receptor kainate receptors larval neuromuscular junction larval NMJ loss of function metabotropic mossy fiber motor axon motor neuron muscle mutants show nerve bundle neuromuscular junction neuronal expression neurotransmitter NMJ growth NMJ overgrowth phenotype NMJ phenotype non-NMDA null alleles number and branching oocytes paralysis phenotype pathway phenotype of clu phenotype seen postsynaptic presynaptic Quantification of average recessive gain rescue room temperature Schuster screen seen in clu significantly different Student's T-test suppress the overgrowth synaptic boutons synaptic growth synaptic morphology synaptic plasticity transgene wallenda wild-type Clumsy