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abnormal platelet activity acute administration agents anemia antibody anticoagulant aspirin assays associated blood coagulation blood vessels cause Chapter circulating anticoagulant clinical clot retraction clotting factors coagulation factors coagulation proteins collagen concentrates corticosteroids coumarin defective deficiency diagnosis disorders of blood disseminated intravascular coagulation dose drug elevated platelet counts enzymes factor IX factor VIII FDP-fdp fibrin fibrinogen fibrinolysis fresh frozen plasma gastrointestinal hemophilia hemor hemorrhagic diathesis hemostasis hemostatic Hemostatic Function hemostatic plug heparin hepatic immunologic increased infection inherited disorders inhibition inhibitor initial laboratory lesions levels of AHG levels of factor liver disease megakaryocytes normal occur partial thromboplastin pathway patients with hemophilia phospholipid Plate platelet aggregation platelet function platelet production prolonged prothrombin reaction red cells release response result serum splenectomy spontaneous surgery synthesis Table Tests of Hemostatic throm thrombin thrombocytopenia thrombocytopenic purpura thrombocytosis thrombosis thrombotic tients tion titer transfusion trauma treatment usually Variable vascular vitamin Willebrand's syndrome