Neuroimmunomodulation: Perspectives at the New Millennium, Volume 917
New York Academy of Sciences, 2000 - Medical - 987 pages
These proceedings focus on different areas of research, with special emphasis on relating the state of the art (basic) neuroimmunomodulation research to its potential practical application in specific fields. Among these, the role of pro-and anti-inflammatory cytokines in the central nervous system; peripheral mechanisms of neuroimmunomodulation; behavioural studies and immunity; and neuroimmunomodulation correlates in autoimmune disease represent areas of particular interest. Also highlighted are studies related to the role of melatonin as an immunomodulatory hormone (an area of explosive growth), as well as the emerging field of neuroendocrine regulation of haematopoiesis. Clinical studies in cancer, allergy, AIDs and other infectious diseases will focus upon neuroimmunomodulation-based mechanisms, and suggest new therapeutic approaches.
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The Mechanism of Action of Cytokines to Control the Release of Hypothalamic
Bidirectional Heterologous Desensitization of Opioid and Chemokine Receptors
Neurohormones and Catecholamines as Functional Components of the Bone
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Acad ACTH activity adrenal agonist animals antibody antigen apoptosis arthritis autoimmune disease binding Biol blood bone marrow brain cancer cellular chemokine chronic Clin corticosterone cortisol cultures CXCR2 cytokines decrease differentiation effects Endocrinology endogenous endotoxin enhanced experimental fever FIGURE gland glucocorticoids GnRH growth factor hormone HPA axis human hypothalamic IFN-Y immune cells immune function immune response immune system Immunol increase induced inflammation inflammatory inhibition inhibitor injection interactions interleukin-1 leptin leukocytes levels LHRH lymphocytes macrophages mechanisms mediated melatonin mice modulation molecular monocytes mRNA murine Natl nerve nervous system neuroendocrine neurons neuropeptides Neurosci NF-kB NK cells o-MSH opioid pathway patients peptide peripheral PGE2 pineal pituitary plasma Proc production proinflammatory prolactin proliferation protein receptor regulation release role secretion serum signaling significantly spleen steroid stimulation stress studies suppression T-cell thymic thymocytes thymus tion tissue TNF-o TNFo treatment tumor necrosis vitro vivo