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accidental poisoning acute lethality tests Additional tests adverse effect agency Ames test animal studies animals in product bacteria cause chemical agent chemical compound chemical products chemical substances chemical's CHRONIC STUDIES cleaner clinical trials conducted in rats consumer products corrosive CPSC death determine Draize test early screening effects of chemical exposed exposure federal growth medium harmful effects household products information needed Initial screens injury labeling laboratory animals limit test living system manufacturers marketing Mutagenicity studies mutation nonanimal methods nonanimal testing methods number of animals organ cultures personal care products pharmaceutical Physiological processes Poison Control Centers potentially harmful pre-marketing approval procedures prod product safety testing protect rabbits reduce the number safety data safety information scientific side effects skin and eye small number species subchronic evaluation sulfa drug sumer test animals tested on animals thalidomide tion tissue toxic chemicals toxicity testing ucts vitro tests whole animal tests