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RNA Interference:

Application to Drug Discovery and Challenges to Pharmaceutical Development (Google eBook)
Front Cover
Paul H. Johnson
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John Wiley & Sons, Mar 1, 2011 - Medical - 328 pages
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
  

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Contents

CONTENTS
NUCLEIC ACIDS AS REGULATORY MOLECULES 12
USE OF SIRNA OLIGONUCLEOTIDES TO STUDY
GENOME SCANNING BY RNA INTERFERENCE 76
DISCOVERY OF NEW SIRNA DELIVERY AGENTS 125
SIRNA DELIVERY VEHICLES 174
INTERFERON CYTOKINE INDUCTION AND OTHER
APPLICATION OF RNA INTERFERENCE
INDEX 307
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About the author (2011)

PAUL H. JOHNSON, PhD, is a cofounder and Chief Scientific Officer at PhaseRx, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffrey Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

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