Beginnings of Cellular Life: Metabolism Recapitulates Biogenesis

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Yale University Press, 1993 - Science - 208 pages
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"This book is an extraordinary integration of a lifetime of thought on the subject by an exceptional scholar. Morowitz logically, consistently, and persuasively moves to define arguments that will influence thought in a fundamental realm of biology." -Donald M. Engelman, Yale University "Morowitz develops a model of the origin of life in which cells originate first, proteins follow, and genes evolve last. This model contradicts conventional wisdom but has the distinct advantage of being testable; and is supported by evidence mustered from biology, biochemistry, and biophysics. Morowitz['s] expertise in all three disciplines is impressive."-Francisco J. Ayala, Dept. of Ecology and Evol. Biology, University of California, Irvine "In this short and clearly written book, Morowitz explores the origins of life. . . . His objective is elegantly achieved. . . . A stimulating analysis . . . [and] an excellent read." -A. E. Douglas, Times Higher Education Supplement "[A] book rich in provocative and stimulating ideas. . . . I recommend it to anyone who has ever thought seriously about the origin of life." -Vincent P. Cirillo, Quarterly Review of Biology
  

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Contents

The Nature of the Problem
1
The Study of Origins
10
The TopDown Approach
28
Generalizations from Contemporary Biology
38
The Minimal Cell
59
The BottomUp Approach
69
Chemical Elements Hydrophobicity and
85
The Logic of Replication
98
Energy Complexity and Organization
113
Underlying Chemical Mechanisms
133
Networks
150
Lessons from Contemporary Biochemistry
160
The Scenario
172
Index
187
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