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acetyl acetylsalicylic acid action Alix Alphons analgesic angiomas appeared ascorbic acid aspirin became benzoic acid bleeder bleeding diseases bleeding tendency blood coagulation capillaries carrier cause century chemical clinical clotting factor coenzyme compound conjugation connective tissue control of bleeding Copernicus daughter defect deficiency detoxication developed diagnosis died diet drug excretion factor VIII genes genetic hemophilia hemophilic hemorrhagic disease Hemostasis hemostatic Hess hippuric acid Hospital human important inherited Inosithin interesting laboratory lack later Leopold lesions medicine metabolism mother Nicki normal nosebleeds nutritional obtained occurred one-stage prothrombin Osler pain patient pedigree phenylacetic acid phospholipid physician plasma platelet potato primate family Prince Princess prolonged prothrombin consumption Queen Victoria Rasputin recognized Rendu-Osler disease rheumatic royal family Russia salicin salicylic acid scurvy severe simple sodium salicylate soybean phospholipid story supply telangiectasia Tenna thrombin tion tourniquet test transfusion Tsar Tsarevitch Tsarina uric acid vita vitamin Q Wisconsin