Basic Clinical Radiobiology
This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect. A variety of new authors have contributed to this revision, who, together with the new Editorial team, have used their significant international teaching experience to ensure the content remains clear and comprehensive, and as valuable to the trainee as it is to the established radiation oncologist.
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Irradiationinduced damage and the DNA damage response
how when and why cells die
Quantifying cell kill and cell survival
17 other sections not shown
apoptosis assay biological effect brachytherapy cell cycle cell death cell killing cell survival cellular cent Chapter checkpoints chemotherapy clinical clonogenic cells DNA damage DNA repair Dorr dose fractions dose per fraction dose rate dose-rate dose-response curve drugs DSBs EGFR endpoints EQD2 etal experimental FDG-PET fractionated irradiation function genes growth factor head and neck human tumours hyperfractionation hypoxia hypoxic hypoxic cells imaging increase inhibitors Int J Radiat IntJ IntJ Radiat Oncol irradiation isoeffective late effects LQ model lung cancer misonidazole mitosis molecular mouse mucositis neck cancer normal tissues Oncol Biol Phys oral mucosa overall treatment Overgaard oxygen parameters pathways patients phase proliferation protein proton Radiat Oncol Biol radiation dose radiation effects radiation therapy radiation-induced radiobiological radiobiology radiosensitivity Radiother radiotherapy ratio re-irradiation reduced repopulation risk second cancers sensitivity spinal cord squamous cell carcinoma stem cells studies survival curve therapeutic tion tolerance total dose toxicity trials tumour control