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active allergen allergic allograft anaphylatoxin anaphylaxis animals anti GBM antibody antibody production atopy Azathioprine basophils binding blood bone marrow cellular immune chemical chemotactic circulating clinical complement system components corticosteroids cyclophosphamide cytes cytotoxic delayed hypersensitivity disease donor drugs effect effector erythrocytes experimental function gene glomerular guinea pig hapten histamine histocompatibility HL-A human hypersensitivity reactions IgE antibody immune complexes immune response immunogenic immunoglobulin immunological immunosuppression induced inhibition injection interaction leukocytes light chain lymph nodes lymphocytes lymphoid cells macrophages malignancy mast cells mechanism mediators of anaphylaxis membrane mice mitogen molecular weight myeloma myeloma protein nephritis nonspecific normal paracortical areas patients peripheral permeability phocytes platelets PMN's protein react reaginic receptors rejection release renal allograft result sensitive cells sera serum specific antigen stimulated synthesis thymectomy thymus tion tissue transfer factor transplantation antigens Triggering tumor tumor cells tumor specific vasoactive amines virus vitro vivo