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accident acid activity acute adults airway anaesthesia anaesthetist Annals of Surgery Arturson bacterial blood loss body surface area burn injury burn wound burned patients Burns Centre burns unit cardiac cause cells chemical clinical concentration cytokines damage decrease dermatome dermis donor area dressings early excision effect electrical injury energy expenditure epithelial excision and grafting exposure extensive burns factors fire fluid function glucose heat hospital hours postburn hypermetabolism hyponatraemia hypovolaemia increased infection inflammatory infusion inhalation injury intake intravenous intubation Journal of Trauma Lawrence J C levels lung lymphocyte macrophages Medical membrane metabolic mortality probability mOsm necrosis neutrophil nitrogen normal Nutrition occur oedema osmolality output oxygen Parenteral plasma Plastic pressure protein Pruitt B A pulmonary renal failure respiratory response result resuscitation sepsis septicaemia serum skin grafting smoke inhalation sodium solution surgical TBSA temperature therapy tion tissue treatment urine volume Wilmore wound healing