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activity aeration amino amylases antibiotics Applied Microbiology Aspergillus nidulans Aspergillus niger Aspergillus oryzae bacteria batch cultures Biochemical Biochemistry biological biosynthesis carbohydrate carbon source cell cellulose cephalosporin chemical Chemistry chemostat citric acid Claviceps purpurea compost compounds concentration conidia continuous culture cultivation cycle dilution rate disease effect enzymes ergot alkaloids exponential factors filamentous fungi formation fungal fungal spores fungus Fusarium genes genetic germination gibberellins gluconic acid glucose griseofulvin growing Hesseltine hyphae industrial inhibition inoculated inoculum isolated itaconic acid Journal kinetics London material maximum mechanisms medium metabolism method Micro micro-organisms microbial Microbiology mould Mushroom Science mutants mycelial mycelium nitrogen nutrient obtained organism oxidation oxygen Patent pathways pellet Penicillium chrysogenum Pirt production proteases protein Rhizopus Righelato sclerotia secondary metabolites soya specific growth rate spores sporulation starch steroids strains studies submerged culture substrate sugar surface synthesis temperature tion toxic transformation Trinci Vezina yeast yield