Tumor Models in Cancer Research
Beverly A. Teicher
Humana Press, Jan 1, 2002 - Medical - 708 pages
Cancer researchers have made significant progress over the years by developing appropriate and accurate animal disease models, the most important being transplantable rodent tumors. In Tumor Models in Cancer Research, Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in tumor model research. The wide array of model systems detailed form the basis for the selection of both compounds and treatments that go into clinical testing of patients, and include syngeneic, human tumor xenograft, orthotopic, metastatic, transgenic, and gene knockout models. These models represent the efforts of many investigators over the years and approach, with increasing precision, examples that serve as guides for the selection of agents and combinations for the treatment of human malignancy. Synthesizing many years of experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.
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