Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques

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Cambridge University Press, Jan 1, 2002 - Medical - 523 pages
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Functional Magnetic Resonance Imaging (fMRI) is now a standard tool for mapping activation patterns in the human brain. This highly interdisciplinary field involves neuroscientists and physicists as well as clinicians, and the range, flexibility and sophistication of the techniques being used are increasing rapidly. In this book, Richard Buxton, a leading authority on fMRI, provides an invaluable introduction to how fMRI works, from basic principles and the underlying physics and physiology, to newer techniques such as arterial spin labeling and diffusion tensor imaging. The book also includes discussion of how fMRI relates to other imaging techniques (such as Positron Emission Tomography, or PET) and a guide to the statistical analysis of fMRI data. This book will be useful both to the experienced researcher using fMRI, and the clinician or researcher with no previous knowledge of the technology.
  

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Contents

AN OVERVIEW OF FUNCTIONAL MAGNETIC RESONANCE IMAGING
1
Introduction to Functional Neuroimaging
3
Energy Metabolism in the Brain
4
Cerebral Blood Flow
22
Brain Activation
41
Introduction to Functional Magnetic Resonance Imaging
63
Nuclear Magnetic Resonance
64
Magnetic Resonance Imaging
86
MRI Techniques
249
Noise and Artifacts in Magnetic Resonance Images
274
PRINCIPLES OF FUNCTIONAL MAGNETIC RESONANCE IMAGING
307
Perfusion Imaging
309
Principles of Tracer Kinetics
310
Contrast Agent Techniques
330
Arterial Spin Labeling Techniques
351
Blood Oxygenation Level Dependent Imaging
389

Imaging Functional Activity
104
PRINCIPLES OF MAGNETIC RESONANCE IMAGING
121
The Nature of the Magnetic Resonance Signal
123
Basic Physics of Magnetism and NMR
124
Relaxation and Contrast in MRI
155
Diffusion and the MR Signal
185
Magnetic Resonance Imaging
217
Mapping the MR Signal
218
The Nature of the Blood Oxygenation Level Dependent Effect
390
Mapping Brain Activation with BOLDfMRI
417
Statistical Analysis of BOLD Data
445
Efficient Design of BOLD Experiments
473
The Physics of NMR
493
Index
511
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About the author (2002)

Richard B. Buxton is Professor of Radiology and Director of Magnetic Resonance Research at the University of California at San Diego.

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