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05 Mean Frequency Alzheimer's Disease animals with bilateral animals without HPC behavior and wayfinding bilateral hippocampal lesions bilateral HPC damage bilateral HPC lesions Bilaterals N=5 N=7 burr hole change in directional change in wayfinding control group Controls Bilaterals N=5 Cue Navigation Task days of testing difference in wayfinding differences in mean different from controls directional heading error distracting stimulus present Distraction Task Controls distractor experimental animals experimental group exploratory behavior frequency of exploratory Frequency of Quarter frequency of rearing Fromes goal platform introduction Kruskal-Wall is test Kruskal-Wallis test landmarks larger directional heading mean swim N=7 Day Navigation Task Controls O'Keefe & Nadel O'Keefe and Nadel paws Persons with ADC place cells quarter turns reveal significant differences significant change Significantly different spatial disorientation Task Controls Bilaterals task with distracting temporal lobes test days 13 testing environment Therrien visual cue marking visually distracting element visually distracting stimulus Wayfinding Ability