DNA fingerprinting: state of the science
The objective of this book is to equip forensic scientists, biologists, ecologists, geneticists, biochemists and molecular biologists with up-to-date, authoritative information on, and research perspectives in the field of polymorphic DNA tandem repeat polymorphisms (DNA fingerprinting). All aspects of the field are covered. Beginning with an authoritative general introduction to DNA fingerprinting, the book reviews basic knowledge, including the nature, genomic arrangements and variability of tandem repeated sequences. The first selection also addresses new approaches to the study of genomic variability, including PCR with random primers and the new technique of capillary electrophoresis. The second section deals with the application of DNA fingerprinting to concrete problems in our society. It starts with a presentation of the new revolutionary technique of MVR-PCR and a review of transcribed polymorphic microsatellites and their role in the etiology of important human diseases. This is followed by an extensive discussion of the controversial issue of the population genetics of tandem repeat polymorphisms and the utilization of DNA fingerprinting in paternity testing and criminal analysis. The third part includes applications in the study of topics as varied as taxonomy, genetic improvement and population ecology in microorganisms, plants, and animals, ranging from protozoa to primates.
The authors are the foremost experts in the DNA fingerprinting field. By virtue of its scope and depth this book answers a long-standing need for an authoritative text in DNA fingerprinting.
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B Tandemly Repeated DNA Sequences in Eukaryotic Genomes
G Vergnaud D Gauguier J J Schott D Lepetit V Lauthier
B Olaisen M Bekkemoen P HoﬂOlsen and P Gill
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allele frequencies ampliﬁcation analysis analyzed band sharing band-sharing blot Budowle Caucasian cDNA cells Chakraborty chromosome clones cruzi databases deﬁned deﬁnition detected diﬂerent digestion distribution DNA ﬁngerprinting DNA fragments DNA proﬁles DNA sequences DNA typing electrophoresis Epplen JT estimates ﬁrst ﬁve ﬂanking forensic fragile X syndrome gene genomic DNA genotype groups Haelll heterozygosity Hinfl Hum Genet human DNA human genome hybridization hypervariable loci Hypervariable minisatellite identiﬁcation individuals intron isolated Jeffreys Jeﬂreys linkage locus male Mapuche markers mating methods microsatellites molecular multilocus DNA ﬁngerprinting mutation mutation rate myotonic dystrophy Nucleic Acids Res number of bands obtained offspring oligonucleotide probes Pena polymerase chain reaction polymorphic primers protein Reference population region relationships repeat units repetitive DNA signiﬁcant simple repeat simple sequence Southern blot species speciﬁc strains tandem repeats telomere tion unrelated variability Vergnaud VNTR VNTR loci Yanomami