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a-tocopherol Acta activity agents allopurinol alterations animals anthracycline antioxidant arrhythmias Biochem Biol Biophys Boston/Dordrecht/Lancaster calcium canine cardiac Cardiol catalase cellular Chem Circ Circulation Clin concentration coronary occlusion damage decrease diabetic dogs effect electron enzyme fatty acids formation free radical scavengers Fridovich glutathione peroxidase GSSG efflux hydrogen peroxide hydroxyl radical increased induced inhibition inhibitor intracellular ischemia and reperfusion ischemia/reperfusion ischemic isolated leukocytes levels lipid peroxidation liver Lucchesi lysosomes McCord mechanisms mediated Meerson membrane metabolism microsomal mitochondrial muscle myocardial infarction myocardial ischemia myocardial stunning myocytes necrosis neutrophils observed oxidative stress oxygen free radicals oxygen radicals perfused Pharmacol phospholipid Physiol plasma postischemic dysfunction Proc production protection proteins rabbit hearts rat heart reaction recovery reduced reoxygenation reperfusion-induced arrhythmias role Russ sarcoplasmic reticulum shown significant significantly Singal species studies stunned myocardium suggest sulfhydryl superoxide dismutase tissue toxicity ventricular vivo X-XO xanthine dehydrogenase xanthine oxidase