Flavonoids in Health and Disease, Second Edition (Google eBook)

Front Cover
Catherine A. Rice-Evans, Lester Packer
CRC Press, May 20, 2003 - Medical - 504 pages
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Revised and expanded, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health. The book examines the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function.The Second Edition contains new discussions on the potential of dietary flavonoids to attenuate neurological dysfunction and degeneration, developments in gene expression and genomics for identification of therapeutic targets and markers of disease, and the mechanisms regulating flavonoid bioavailability.

  

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Contents

Occurrence and Analysis
1
Flavonoids in Herbs
43
The Relationship Between the Phenolic Composition
71
Characterization Chemical and Biological Properties
97
Synthesis Identification Quantification and Chemical
123
Investigation of Flavonoids and Their In Vivo Metabolite
145
Cell Interactions In Vivo and In Vitro
205
Neuroprotective Agents? Modulation of Oxi
233
Gene Modulation of HaCaT Cells Induced by Pine Bark
303
Cytoprotective and Cytotoxic Effects of Flavonoids
309
Absorption Metabolism and Bioavailability
349
Metabolism in the Small Intestine and Gastrointestinal Tract
363
Absorption of Quercetin Glycosides
391
Bioavailability of Flavanol Monomers
413
Absorption and Metabolism of Hydroxycinnamates
441
Index
459

Mitochondrial Actions of Flavonoids and Isoflavonoids
273

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Page v - The series will also highlight the major natural antioxidant enzymes and antioxidant substances such as vitamins E, A, and C, flavonoids, polyphenols, carotenoids, lipoic acid, and other nutrients present in food and beverages.
Page iv - ... protein misfolding or aggregation. This reducing environment is maintained by oxidative metabolism and by the action of antioxidant enzymes and substances such as glutathione, thioredoxin, vitamins E and C, and enzymes such as superoxide dismutase (SOD), catalase, and the selenium-dependent glutathione and thioredoxin hydroperoxidases, which serve to remove reactive oxygen species.
Page iv - Thus, there is a delicate balance between oxidants and antioxidants in health and disease. Their proper balance is essential for ensuring healthy aging. The term oxidative stress indicates that the antioxidant status of cells and tissues is altered by exposure to oxidants. The redox status is thus dependent on the degree to which a cell's components are in the oxidized state. In general, the reducing environment inside cells helps to prevent oxidative damage. In this reducing environment, disulfide...

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