Genes and Cardiovascular Function (Google eBook)
Springer Science & Business Media, Aug 9, 2011 - Medical - 280 pages
Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
What people are saying - Write a review
We haven't found any reviews in the usual places.
activity allele angiotensin aorta aortic associated binding Biochem Biol Chem blood pressure Brugada syndrome Ca2+ candidate genes cardiac hypertrophy cardiomyocytes Cardiovasc Res Cardiovascular cell cycle channel cholesterol Circ Res Clin clinical collagen coronary artery cyclin decreased diabetes disease dysfunction effect embryonic enzyme flecainide function gene expression genetic genome genotype Heart Circ Physiol heart failure human hypertension hypertrophy increased inhibition interactions ischemic isoforms kinase knockout left ventricular levels lipid LQT3 mechanisms MELAS metabolism mice mitochondrial DNA mmHg molecular mouse mRNA muscle mutations myocardial infarction myocardium myocytes Na+-Ca2+ exchanger NCX1 P-TEFb pathway patients phenotype Physiol Heart Circ plasma polymorphism population PPAR PPAR-a protein rat heart receptor regulation remodeling response risk factors role sarcomere scleraxis SCN5A sequence signaling SNPs sodium Springer Science+Business Media stress syndrome synthesis systolic tion tissue transgenic tRNALeu(UUR tubulogenesis up-regulation variants vascular VEGF