Drug Delivery: Principles and Applications

Binghe Wang, Teruna J. Siahaan, Richard A. Soltero

John Wiley & Sons, May 13, 2005 - Science - 464 pages

An indispensable tool for those working at the front lines of new drug development
Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery.
Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures.
Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery

Contents

• 1 Factors That Impact the Developability of Drug Candidates An Overview: 1
• 2 Physiological Biochemical and Chemical Barriers to Oral Drug Delivery: 15
• 3 Pathways for Drug Delivery to the Central Nervous System: 29
• 4 Physicochemical Properties Formulation and Drug Delivery: 57
• 5 Targeted Bioavailability A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery: 73
• 6 Presystemic and FirstPass Metabolism: 83
• 7 Cell Culture Models for Drug Transport Studies: 103
• 8 Prodrug Approaches to Drug Delivery: 125
• 9 ReceptorMediated Drug Delivery: 167
• 10 Oral Protein and Peptide Drug Delivery: 189
• 11 Metabolic Activation and Drug Targeting: 201
• 12 UltrasoundMediated Drug Delivery: 245
• 13 Polycationic Peptides and Proteins in Drug Delivery Focus on Nonclassical Transport: 279
• 14 Gene Therapy and Gene Delivery: 305
• 15 Parenteral Formulation for Peptides Proteins and Monoclonal Antibodies Drugs A Commercial Development Overview: 321
• 16 Pulmonary Drug Delivery Pharmaceutical Chemistry and Aerosol Technology: 341
• 17 AntibodyDirected Drug Delivery: 363
• 18 Efflux Transporters in Drug Excretion: 381
• 19 Liposomes as Drug Delivery Vehicles: 411
• 20 Regulatory and Intellectual Property Issues in Drug Delivery Research: 435
• Index: 443

About the author

BINGHE WANG, PhD, is a professor and Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scientist in the Department of Chemistry, Georgia State University. He is Editor in Chief of Medicinal Research Reviews and a member of the Long-Range Planning Committee of the American Chemical Society, Division of Medicinal Chemistry.

TERUNA SIAHAAN, PhD, is a professor in the Pharmaceutical Chemistry Department, University of Kansas, and a Fellow of the American Association of Pharmaceutical Scientists.

RICHARD A. SOLTERO, PhD, President of PharmaDirections, Inc., is an executive- level scientist with extensive experience managing multisite and multinational pharmaceutical and biotechnology labs.

Bibliographic information

• Title: Drug Delivery: Principles and Applications; Volume 1 of Wiley Series in Drug Discovery and Development
• Authors: Binghe Wang, Teruna J. Siahaan, Richard A. Soltero
• Publisher: John Wiley & Sons, 2005
• ISBN: 0471475718, 9780471475712
• Length: 464 pages
• Subjects: Science / Chemistry / Industrial & Technical