Gulf War and Health:: Volume 1. Depleted Uranium, Pyridostigmine Bromide, Sarin, and Vaccines

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National Academies Press, Nov 28, 2000 - Medical - 432 pages
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The men and women who served in the Gulf War theater were potentially exposed to a wide range of biological and chemical agents. Gulf War and Health: Volume 1 assesses the scientific literature concerning the association between these agents and the adverse health effects currently experienced by a large number of veterans.
  

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Contents

Introduction
27
ADDRESSING GULF WAR HEALTH ISSUES Past and Current Efforts
28
THE GULF WAR SETTING
32
SCOPE OF THE REPORT
35
ORGANIZATION OF THE REPORT
36
Illnesses in Gulf War Veterans
39
REGISTRY PROGRAMS
40
EPIDEMIOLOGIC STUDIES OF VETERANS SYMPTOMS AND GENERAL HEALTH STATUS
43
SUMMARY OF TOXICOLOGY
187
CONCLUSIONS
198
Pyridostigmine Bromide
207
TOXICOLOGY
209
HUMAN STUDIES
222
CONCLUSIONS Acute Effects
250
Vaccines
267
ISSUES IN IDENTIFYING ADVERSE EFFECTS
268

EPIDEMIOLOGIC STUDIES OF SPECIFIC HEALTH ENDPOINTS
54
LIMITATIONS OF PAST STUDIES AND ONGOING STUDIES
60
CONCLUSIONS
62
Methodology
69
METHODS OF GATHERING AND EVALUATING THE EVIDENCE
70
TYPES OF EVIDENCE
71
CONSIDERATIONS IN ASSESSING THE STRENGTH OF THE EVIDENCE
78
SUMMARY OF THE EVIDENCE
81
COMMENTS ON INCREASED RISK OF ADVERSE HEALTH OUTCOMES AMONG GULF WAR VETERANS
84
Depleted Uranium
89
TOXICOLOGY
94
DESCRIPTION OF THE STUDIES
106
HUMAN HEALTH EFFECTS OF URANIUM
121
CONCLUSIONS
159
Sarin
169
ACUTE CHOLINERGIC SYNDROME
170
POSSIBLE US TROOP EXPOSURE
172
SARIN TOXICOLOGY
174
CYCLOSARIN TOXICOLOGY
186
ANTHRAX VACCINE
272
BOTULINUM TOXOID
287
MULTIPLE VACCINATIONS
294
SQUALENE
307
CONCLUSIONS
312
Research Recommendations
325
DEPLETED URANIUM
326
SARIN
327
PYRIDOSTIGMINE BROMIDE
328
VACCINES
329
Appendixes
331
Scientific Workshop Agenda
333
Public Meeting Agendas
336
Methods of Identifying and Collecting the Literature
339
Gulf War Illnesses and Recognizing New Diseases
342
Effects of LongTerm Exposure to Organophosphate Pesticides in Humans
366
Acronyms and Abbreviations
378
Index
383
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