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abnormal acid activity acute leukemia agents Amer animals antibody antigen ara-C areas artery associated biochemical biopsy bladder blood bone breast cancer cancer cells Cancer Inst Cancer Res carcinogenic carcinoma cellular cervix chemical chemotherapy chromosomal clonogenic colon cyclophosphamide cytologic detection diagnosis dose drug effect enzyme etiology evaluation excretion experimental factors genetic growth hepatoma histologic Hodgkin's disease host human immune immunologic incidence increased indicate induced inhibition injection involved irradiation karyotypic kidney lesions leukemic levels liver lung lymph nodes lymphocytes lymphoma M. D. Anderson Hospital malignant marrow mass Medicine melanoma ment metabolic metastases methotrexate mice mouse neoplasia neoplasms normal observed occur oncogenic patients plasma population primary procedures proliferation protein radiation radioactivity rats relatively renal response Roentgen sarcoma scanning serum skin specific studies techniques therapeutic therapy thyroid tion tissue toxicity treatment tumor cells viral virus viruses vitro