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HI Studies with Tetracycline Analogues
Resistance of Bacteria to the Tetracyclines
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50S ribosomal subunits 70S ribosomes Acad Acta actinomycin action of Sm action of streptomycin alanine amino acids antibacterial antibiotic assay aureus azaserine Bact bacteria bactericidal base pair binding of aminoacyl-tRNA binding of tetracycline binding sites Biochem Biol biophys carbomycin cell wall cell-free Chem chemical Chemother chromophore complex culture cycloserine d-alanine deoxyribonucleic acid DNA synthesis doses drug enzyme erythromycin Escherichia coli ethambutol formation fusidic acid growth guanine hydrogen hypothesis incorporation infections interaction isoniazid isonicotinic acid lincomycin mechanism of action messenger RNA metabolism Miscoding mode of action molec molecular molecule mycin nalidixic acid novobiocin nucleic acid nucleotides observed oleandomycin penicillin peptide poly polymerase polysomes Proc protein biosynthesis protein synthesis purines puromycin pyrazinamide reaction replication resistance ribo ribonucleic acid ribosomes ristocetin sensitive specific spiramycin staphylococci strains strand streptomycin structure studies tetracycline to ribosomes therapy Toxic transfer RNA tRNA tuberculostatic ug/ml uptake vitro vivo Wash