Lectins and CancerHans-Joachim Gabius, Sigrun Gabius Molecular recognition undoubtedly governs any aspect of cellular interaction. To understand tumor cell growth regulation and spread, analysisof protein carbohydrate interactions can contribute to lead to the establishment of rational methods for diagnosis and therapy. Chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumor cells and tumor sections and the usefulness of a lectin from a plant extract as potent immunomodulator indicate the prospect for a place of such techniques in pathology and oncology. |
Contents
Molecular basis of lectincarbohydrate interactions | 1 |
Tools for | 27 |
Lectin histochemistry of human thyroid tumors | 41 |
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acid activity adhesion molecules affinity amino antigens Avvakumov Baldo Bardosi Barondes binding sites Biochem Biol Chem biological biotinylated Brady RO carbohydrate carbohydrate-binding carcinoma cell adhesion cell lines cell surface cellular complex conjugates culture detected differentiation effect endogenous lectins enzyme fucose Gabius HJ Gaucher disease glucocerebrosidase glycans glycoconjugates glycoproteins glycosylation growth histochemical human immune inhibition injected interactions isolectin Kuchler lactose lectin binding lectin expression leukemia leukemic ligands liposomes liver Lotan lung lymphocytes lymphoma malignant mannose metastases mice mistletoe lectin mitogenic ML-I molecular monoclonal antibody Monsigny Müller murine myelin neoglycoenzymes neoglycoproteins normal oligodendrocyte oligosaccharide patients plasma membrane primary tumor proteins reaction renal cell carcinoma serum Sharon N specific spermatozoa spleen staining Steinhausen steroid Strel'chyonok structure studies sugar receptors target therapy tissue treatment tumor tumor cells Uhlenbruck variants VINCENDON G vitro vivo ZANETTA J-P zona pellucida µg/ml