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Appraisal of the impact of alternatives to animal
Conclusion and future perspectives
alternative methods alternatives to animal Alternatives To Laboratory Amsterdam Animal Alternatives animal experiments animal testing animal trials animal welfare animal welfare organisations Animals Procedures Committee applied Belgian Statute Book Belgium biological biotransformation BPAM carried Cauteren cell cultures centres chemical substances Chorioallantoic Membrane concerning cytotoxicity databank dose ECVAM effects Elsevier ESAC etal Ethics van Zutphen Euro European Communities European Directive evaluation experimental animals Guillouzo guinea pigs Hendriksen hepatocytes human hybridoma Inserm Janssen Research Foundation LFM & Balls LLNA Lymph Node metabolism methods to animal models molecule monoclonal antibodies Netherlands neutral red number of animals number of experimental OECD OECD guideline Official Journal pain and distress phototoxicity pre-clinical Prince Laurent procedures reduction Replacement of Animals Rogiers scientific research skin specific techniques test substance tion tissue toxicity toxicity trials Toxicology in Vitro vaccines validation of alternative veterinary vitro methods vitro tests vivo Welfare and Ethics xenobiotics Zutphen LFM